AGN 193109

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5758/10
AGN 193109 | CAS No. 171746-21-7 | Retinoic Acid Receptor Antagonists
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Description: High affinity pan-RAR antagonist

Chemical Name: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid

Purity: ≥98%

Product Details
Citations (3)
Reviews (1)

Biological Activity

High affinity pan-retinoic acid receptor (RAR) antagonist (Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits no significant affinity for retinoic X receptors.

Technical Data

M.Wt:
392.49
Formula:
C28H24O2
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
171746-21-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AGN 193109

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Near complete ablation of RA-induced transcription in MCF7 cells
By Anonymous on 11/02/2019
Application: Species: Human

AGN193109 was dissolved to a concentration of 20 mM in DMSO with no solubility issues. Retinoic acid (10 uM), DMSO, or RA + AGN193109 (1 uM) was added to MCF7 cells for 5 hours following by qPCR analysis of a reporter gene normalized to GAPDH levels. There was no apoptosis in MCF7 cells at 1 uM inhibitor for up to 9 hours even though this has been reported elsewhere. 1 uM of inhibitor almost completely ablated RA induced gene transcription by qPCR. HX531 performed slightly better in our analysis, but the experiment was only performed once.


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