AGN 193109

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AGN 193109 | CAS No. 171746-21-7 | Retinoic Acid Receptor Antagonists
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Description: High affinity pan-RAR antagonist

Chemical Name: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid

Purity: ≥98%

Product Details
Citations (7)
Reviews

Biological Activity

AGN 193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist (Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits no significant affinity for retinoic X receptors. AGN 193109 promotes the differentiation from mouse embryonic stem cells into paraxial mesoderm. AGN 193109 suppresses primary human cardiovascular smooth muscle cell calcification.

AGN 193109 synthesized to Ancillary Material Grade also available.

Technical Data

M.Wt:
392.49
Formula:
C28H24O2
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
171746-21-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AGN 193109

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