Chemical Name: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid
Biological ActivityHigh affinity pan-retinoic acid receptor (RAR) antagonist (Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits no significant affinity for retinoic X receptors.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells.
Agarwal et al.
Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5
Levi et al.
Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport.
Jaurena et al.
Citations for AGN 193109
The citations listed below are publications that use Tocris products. Selected citations for AGN 193109 include:
3 Citations: Showing 1 - 3
Timed Collinear Activation of Hox Genes during Gastrulation Controls the Avian Forelimb Position.
Authors: Moreau Et al.
Curr Biol 2019;29:35
Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma.
Authors: Jian Et al.
Cell Mol Gastroenterol Hepatol 2018;6:429
Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina.
Authors: Blixt Et al.
Dev Dyn 2018;247:630
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AGN193109 was dissolved to a concentration of 20 mM in DMSO with no solubility issues. Retinoic acid (10 uM), DMSO, or RA + AGN193109 (1 uM) was added to MCF7 cells for 5 hours following by qPCR analysis of a reporter gene normalized to GAPDH levels. There was no apoptosis in MCF7 cells at 1 uM inhibitor for up to 9 hours even though this has been reported elsewhere. 1 uM of inhibitor almost completely ablated RA induced gene transcription by qPCR. HX531 performed slightly better in our analysis, but the experiment was only performed once.