AGN 193109
Tocris Bioscience | Catalog # 5758
Key Product Details
Description
Product Description
AGN 193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist (Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits no significant affinity for retinoic X receptors. AGN 193109 promotes the differentiation from mouse embryonic stem cells into paraxial mesoderm. AGN 193109 suppresses primary human cardiovascular smooth muscle cell calcification.
AGN 193109 synthesized to Ancillary Material Grade also available.
Product Specifications for AGN 193109
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.92 | 10 with gentle warming |
Preparing Stock Solutions for AGN 193109
The following data is based on the product molecular weight 392.49.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.48 mL | 127.39 mL | 254.78 mL |
| 0.5 mM | 5.10 mL | 25.48 mL | 50.96 mL |
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.10 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 26 publications citing the usage of this product.
- Rogers Retinoids repress human cardiovascular cell calcification with evidence for distinct selective retinoid modulator effects. Arterioscler.Thromb.Vasc.Biol. 2020 PMID: 31852220
- Russell Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage. Stem Cell Res. 2018 PMID: 29807258
- Levi Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5 Nat.Commun. 2015 PMID: 26592976
- Jaurena Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Nat.Commun. 2015 PMID: 26101153
- Agarwal AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J.Biol.Chem. 1996 PMID: 8647816
Product Documents for AGN 193109
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for AGN 193109
For research use only
Related Research Areas
Citations for AGN 193109
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Species: HumanAssay Type: In VitroCell Line/Tissue: MCF7Verified Customer | Posted 11/02/2019No obvious apoptosis in cell lines treated with this inhibitor.AGN193109 was dissolved to a concentration of 20 mM in DMSO with no solubility issues. Retinoic acid (10 uM), DMSO, or RA + AGN193109 (1 uM) was added to MCF7 cells for 5 hours following by qPCR analysis of a reporter gene normalized to GAPDH levels. There was no apoptosis in MCF7 cells at 1 uM inhibitor for up to 9 hours even though this has been reported elsewhere. 1 uM of inhibitor almost completely ablated RA induced gene transcription by qPCR. HX531 performed slightly better in our analysis, but the experiment was only performed once.
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