A subtype-selective ligand for the α1B
-adrenoceptor. The pKi
values for binding to rat fibroblast cell membranes expressing α1B
(bovine) and α1D
(rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1
subtypes and α2
receptors in smooth muscle preparations.
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Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors.
Eltze et al.
Structure-activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype.
Saussy et al.
AH 11110A is selective for the α1B-subtype of α1-adrenoceptors.
King et al.