Catalog Number: 0998
Chemical Name: 4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride
Biological Activity
A subtype-selective ligand for the α1B-adrenoceptor. The pKi values for binding to rat fibroblast cell membranes expressing α1B (hamster), α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors.
    Eltze et al.
    Eur.J.Pharmacol., 2001;415:265
  2. Structure-activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype.
    Saussy et al.
    J.Pharmacol.Exp.Ther., 1996;278:136
  3. AH 11110A is selective for the α1B-subtype of α1-adrenoceptors.
    King et al.
    Soc.Neurosci.Abstr., 1994;20:526

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