AH 11110 hydrochloride

Key Product Details

Product Description

AH 11110 hydrochloride is a subtype-selective ligand for the α_1B-adrenoceptor. The pK_i values for binding to rat fibroblast cell membranes expressing α_1B (hamster), α_1A (bovine) and α_1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α₁ subtypes and α₂ receptors in smooth muscle preparations.

Product Specifications for AH 11110 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AH 11110 hydrochloride

The following data is based on the product molecular weight 374.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.67 mL	53.35 mL	106.69 mL
1.25 mM	2.13 mL	10.67 mL	21.34 mL
2.5 mM	1.07 mL	5.33 mL	10.67 mL
12.5 mM	0.21 mL	1.07 mL	2.13 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Saussy Structure-activity relationships of a series of busp. analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 1996 PMID: 8764344
• King AH 11110A is selective for the α_1B-subtype of α₁-adrenoceptors. Soc.Neurosci.Abstr.
• Eltze Failure of AH11110A to functionally discriminate between α₁-adrenoceptor subtypes A, B and D or between α₁- and α₂-adrenoceptors. Eur.J.Pharmacol. 2001 PMID: 11275009

Product Documents for AH 11110 hydrochloride