Catalog Number: 0671
Chemical Name: 6-Isopropoxy-9-xanthone-2-carboxylic acid
Biological Activity
Antagonist at prostaglandin EP1 (pA2 = 6.8) and EP2 (Ki = 350 nM) receptors. Also weakly inhibits DP receptors (pA2 = 4.45).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
    Kiriyama et al.
    Br.J.Pharmacol., 1997;122:217
  2. AH 6809, a prostaglandin DP-receptor blocking drug on human platelets.
    Keery and Lumley
    Br.J.Pharmacol., 1988;94:745
  3. Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2.
    van der Merwe et al.
    J.Pharmacol.Exp.Ther., 2009;329:747
  4. AH6809, a prostanoid EP1-receptor blocking drug.
    Coleman et al.
    Br.J.Pharmacol., 1985;85:273P
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