Catalog Number: 0671
Chemical Name: 6-Isopropoxy-9-xanthone-2-carboxylic acid
Biological Activity
Antagonist at prostaglandin EP1 (pA2 = 6.8) and EP2 (Ki = 350 nM) receptors. Also weakly inhibits DP receptors (pA2 = 4.45).
Technical Data
  • M.Wt:
    298.3
  • Formula:
    C17H14O5
  • Solubility:
    Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    33458-93-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
    Kiriyama et al.
    Br.J.Pharmacol., 1997;122:217
  2. AH 6809, a prostaglandin DP-receptor blocking drug on human platelets.
    Keery and Lumley
    Br.J.Pharmacol., 1988;94:745
  3. Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2.
    van der Merwe et al.
    J.Pharmacol.Exp.Ther., 2009;329:747
  4. AH6809, a prostanoid EP1-receptor blocking drug.
    Coleman et al.
    Br.J.Pharmacol., 1985;85:273P
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AH 6809 include:

6 Citations: Showing 1 - 6
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  1. Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice
    Authors: Liu Et al.
    PLoS One 2016;11:e0165200
  2. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
    Authors: Jansen Et al.
    Dent Res J (Isfahan) 2015;19:210
  3. Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland.
    Authors: Passafaro Et al.
    Br J Pharmacol 2011;8:138
  4. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
    Authors: Chia Et al.
    BMC Pharmacol 2011;11:10
  5. Insulin induces airway smooth muscle contraction.
    Authors: Schaafsma Et al.
    J Pharmacol Exp Ther 2007;150:136
  6. Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors.
    Authors: Walsh and Kinsella
    Br J Pharmacol 2000;131:601

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