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AH 6809

Catalog #: 0671
6 Citations Datasheet / COA / SDS

Discontinued Product

0671 has been discontinued.
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AH 6809 | CAS No. 33458-93-4 | Prostanoid Receptor Antagonists
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Description: EP1 and EP2 receptor antagonist

Chemical Name: 6-Isopropoxy-9-xanthone-2-carboxylic acid

Purity: ≥98%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AH 6809 is an antagonist at prostaglandin EP1 (pA2 = 6.8) and EP2 (Ki = 350 nM) receptors. Also weakly inhibits DP receptors (pA2 = 4.45).

Technical Data

M.Wt:
298.3
Formula:
C17H14O5
Solubility:
Soluble to 100 mM in 1.1eq. NaOH and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
33458-93-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via beta-catenin stabilization.
    Jansen S, Holman R, Hedemann I, Frankes E, Elzinga C, Timens W, Gosens R, de Bont E, Schmidt M
    J Cell Mol Med, 2015;19(1):210-26.
  3. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells.
    Kiriyama et al.
    Br.J.Pharmacol., 1997;122:217
  4. AH 6809, a prostaglandin DP-receptor blocking drug on human platelets.
    Keery and Lumley
    Br.J.Pharmacol., 1988;94:745
  5. Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2.
    van der Merwe et al.
    J.Pharmacol.Exp.Ther., 2009;329:747
  6. AH6809, a prostanoid EP1-receptor blocking drug.
    Coleman et al.
    Br.J.Pharmacol., 1985;85:273P

Product Datasheets

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Citations for AH 6809

The citations listed below are publications that use Tocris products. Selected citations for AH 6809 include:

6 Citations: Showing 1 - 6

  1. Oxidized phospholipid OxPAPC activates TRPA1 and contributes to chronic inflammatory pain in mice
    Authors: Liu Et al.
    PLoS One  2016;11:e0165200
  2. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization.
    Authors: Jansen Et al.
    Dent Res J (Isfahan)  2015;19:210
  3. Cholinergic Autoantibodies from Primary Sjögren's Syndrome Inhibit Mucin Production via Phospholipase C and Cyclooxygenase-2 In the Rat Submandibular Gland.
    Authors: Passafaro Et al.
    Br J Pharmacol  2011;8:138
  4. Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice.
    Authors: Chia Et al.
    BMC Pharmacol  2011;11:10
  5. Ins induces airway smooth muscle contraction.
    Authors: Schaafsma Et al.
    J Pharmacol Exp Ther  2007;150:136
  6. Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors.
    Authors: Walsh and Kinsella
    Br J Pharmacol  2000;131:601

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