Selective SIRT2 inhibitor (IC50
= 15.5 μ
M); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.
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A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase.
Taylor et al.
ACS Chem.Biol., 2011;6:540
The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
Chopra et al.
Cell Rep., 2012;2:1492