Catalog Number: 4754
Chemical Name: N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide
Biological Activity
Selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.
Technical Data
  • M.Wt:
    437.35
  • Formula:
    C19H21BrN2O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    420831-40-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A brain-permeable small molecule reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase.
    Taylor et al.
    ACS Chem.Biol., 2011;6:540
  2. The sirtuin inhibitor AK-7 is neuroprotective in Huntington's disease mouse models.
    Chopra et al.
    Cell Rep., 2012;2:1492

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