AK 7

Catalog # Availability Size / Price Qty
4754/10
4754/50
Class III Histone Deacetylases Inhibitors Small Molecule
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Description: Selective SIRT2 inhibitor; brain penetrant

Chemical Name: N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]benzamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

Selective SIRT2 inhibitor (IC50 = 15.5 μM); displays no effect on SIRT1 or SIRT3. Decreases neuronal cholesterol levels; improves motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Brain penetrant.

Technical Data

M.Wt:
437.35
Formula:
C19H21BrN2O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
420831-40-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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