[Ala^1,3,11,15]-Endothelin

Name: [Ala 1,3,11,15 ]-Endothelin
Brand: Tocris Bioscience
SKU: 1197

Tocris Bioscience | Catalog # 1197

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Product Documents

Selective ETB agonist

Discontinued Product

1197 has been discontinued. View all Endothelin ETB Receptor Agonists products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective ETB agonist

View all Endothelin ETB Receptor Agonists »

Product Description

[Ala^1,3,11,15]-Endothelin is a selective ET_B endothelin receptor agonist (IC₅₀ values are 0.33 and 2200 nM for displacing [¹²⁵I]-ET-1 from ET_B and ET_A receptors respectively).

Product Specifications for [Ala^1,3,11,15]-Endothelin

Molecular Weight

2368.00

Formula

C₁₀₉H₁₆₃N₂₅O₃₂S

Storage

Desiccate at -20°C

CAS Number

121204-87-3

PubChem ID

16143287

InChI Key

NRTWVLDGYXCWHD-IGKRDWOESA-N

SMILES

[H]N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Panek Endothelin and structurally related analogs distinguish between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 1992 PMID: 1312833
Nakamichi Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala^1,3,11,15]ET1. Biochem.Biophys.Res.Commun. 1992 PMID: 1310013

Product Documents for [Ala^1,3,11,15]-Endothelin

Certificate of Analysis

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Product Specific Notices for [Ala^1,3,11,15]-Endothelin

For research use only

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