Catalog Number: 5491
Alternate Names: SPP 100
Chemical Name: (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumarate
Biological Activity
Potent renin inhibitor (IC50 = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Aliskiren: the first renin inhibitor for clinical treatment.
    Jensen et al.
    Nat.Rev.Drug Discov., 2;7:399
  2. Drug discovery for heart failure: a new era or the end of the pipeline?
    Kaye and Krum
    Nat.Rev.Drug Discov., 2007;6:127
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