Aliskiren hemifumarate

Key Product Details

Product Description

Aliskiren hemifumarate is a potent renin inhibitor (IC₅₀ = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.

Product Specifications for Aliskiren hemifumarate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Aliskiren hemifumarate

The following data is based on the product molecular weight 609.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.20 mL	16.40 mL
5 mM	0.33 mL	1.64 mL	3.28 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Kaye and Krum Drug discovery for heart failure: a new era or the end of the pipeline? Nat.Rev.Drug Discov. 2007 PMID: 17268484
• Jensen Aliskiren: the first renin inhibitor for clinical treatment. Nat.Rev.Drug Discov. 2 PMID: 18340340

Product Documents for Aliskiren hemifumarate