Potent renin inhibitor (IC50
= 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Aliskiren: the first renin inhibitor for clinical treatment.
Jensen et al.
Nat.Rev.Drug Discov., 2;7:399
Drug discovery for heart failure: a new era or the end of the pipeline?
Kaye and Krum
Nat.Rev.Drug Discov., 2007;6:127