Catalog Number: 1809
Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride
Biological Activity
Potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A, α1, 5-HT2C, D2 and 5-HT1A respectively). Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.
    Herth et al.
    Bioorg.Med.Chem., 2009;17:2989
  2. Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation.
    Koenig et al.
    Eur.J.Pharmacol., 1987;137:1
  3. Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety.
    Kennett et al.
    Psychopharmacology, 1994;114:90
  4. Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat.
    J.Neural Transm., 1985;61:65

The citations listed below are publications that use Tocris products. Selected citations for Altanserin hydrochloride include:

Showing Results 1 - 2 of 2

  1. Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.
    Authors: Niebert Et al.
    Am J Physiol Regul Integr Comp Physiol
  2. 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.
    Authors: Yu and Yamaguchi
    J Neurophysiol
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