Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride
Biological ActivityAltanserin hydrochloride is a potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A, α1, 5-HT2C, D2 and 5-HT1A respectively). Centrally active following systemic administration in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.
Herth et al.
Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety.
Kennett et al.
Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation.
Koenig et al.
Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat.
J.Neural Transm., 1985;61:65
Citations for Altanserin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Altanserin hydrochloride include:
2 Citations: Showing 1 - 2
Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.
Authors: Niebert Et al.
Am J Physiol Regul Integr Comp Physiol 2011;6:e21395
5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.
Authors: Yu and Yamaguchi
J Neurophysiol 2009;102:752
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