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AM 114

2564 1 Citation Datasheet / COA / SDS
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2564/50
AM 114 | CAS No. 856849-35-9 | Proteasome Inhibitors
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Description: 20S proteasome inhibitor

Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one

Purity: ≥97%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).

Technical Data

M.Wt:
377.01
Formula:
C20H21B2NO5
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
856849-35-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Johns Hopkins University

Background References

  1. A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome.
    Achanta et al.
    Mol.Pharmacol., 2006;70:426
  2. Preferential killing of cancer cells with wild-type p53 by boronic chalcones.
    Achanta et al.
    Proc.Am.Assoc.Cancer Res.Abstr., 2005;46:6162

Product Datasheets

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Citation for AM 114

The citations listed below are publications that use Tocris products. Selected citations for AM 114 include:

1 Citation: Showing 1 - 1

  1. Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
    Authors: Dasgupta Et al.
    PLoS One  2014;9:e103604

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