AM 114

Catalog # Availability Size / Price Qty
AM 114 | CAS No. 856849-35-9 | Proteasome Inhibitors
1 Image
Description: 20S proteasome inhibitor

Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one

Purity: ≥97%

Product Details
Citations (1)

Biological Activity

AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).

Technical Data

Soluble to 10 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Johns Hopkins University

Background References

  1. A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome.
    Achanta et al.
    Mol.Pharmacol., 2006;70:426
  2. Preferential killing of cancer cells with wild-type p53 by boronic chalcones.
    Achanta et al.
    Proc.Am.Assoc.Cancer Res.Abstr., 2005;46:6162

Product Datasheets

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for AM 114

The citations listed below are publications that use Tocris products. Selected citations for AM 114 include:

1 Citation: Showing 1 - 1


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