Catalog Number: 2564
Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one
Biological Activity
Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).
Technical Data
  • M.Wt:
    377.01
  • Formula:
    C20H21B2NO5
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at +4°C
  • CAS No:
    856849-35-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Johns Hopkins University
Background References
  1. A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome.
    Achanta et al.
    Mol.Pharmacol., 2006;70:426
  2. Preferential killing of cancer cells with wild-type p53 by boronic chalcones.
    Achanta et al.
    Proc.Am.Assoc.Cancer Res.Abstr., 2005;46:6162

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