Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one
Biological ActivityInhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome.
Achanta et al.
Preferential killing of cancer cells with wild-type p53 by boronic chalcones.
Achanta et al.
Proc.Am.Assoc.Cancer Res.Abstr., 2005;46:6162
Citation for AM 114
The citations listed below are publications that use Tocris products. Selected citations for AM 114 include:
1 Citation: Showing 1 - 1
Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
Authors: Dasgupta Et al.
PLoS One 2014;9:e103604
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