AM 114
Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one
Purity: ≥97%
Biological Activity
Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome.
Achanta et al.
Mol.Pharmacol., 2006;70:426 -
Preferential killing of cancer cells with wild-type p53 by boronic chalcones.
Achanta et al.
Proc.Am.Assoc.Cancer Res.Abstr., 2005;46:6162
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Citation for AM 114
The citations listed below are publications that use Tocris products. Selected citations for AM 114 include:
1 Citation: Showing 1 - 1
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Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
Authors: Dasgupta Et al.
PLoS One 2014;9:e103604
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