Home / Proteasome Inhibitors / AM 114

AM 114

2564 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2564/10
2564/50
AM 114 | CAS No. 856849-35-9 | Proteasome Inhibitors
1 Image
Description: 20S proteasome inhibitor

Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one

Purity: ≥97%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).

Technical Data

M.Wt:
377.01
Formula:
C20H21B2NO5
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
856849-35-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Johns Hopkins University

Background References

  1. A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome.
    Achanta et al.
    Mol.Pharmacol., 2006;70:426
  2. Preferential killing of cancer cells with wild-type p53 by boronic chalcones.
    Achanta et al.
    Proc.Am.Assoc.Cancer Res.Abstr., 2005;46:6162

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for AM 114

The citations listed below are publications that use Tocris products. Selected citations for AM 114 include:

1 Citation: Showing 1 - 1

  1. Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
    Authors: Dasgupta Et al.
    PLoS One  2014;9:e103604

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for AM 114

There are currently no reviews for this product. Be the first to review AM 114 and earn rewards!

Have you used AM 114?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.