Catalog Number: 5789
Chemical Name: (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid
Biological Activity
Potent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.
Technical Data
  • M.Wt:
    488.48
  • Formula:
    C24H19F3O4S
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1011531-27-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Optimization of GPR40 agonists for type 2 diabetes.
    Liu et al.
    ACS Med.Chem.Lett., 2014;5:517
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