AM 4668

Tocris Bioscience | Catalog # 5789

Potent FFA1 (GPR40) agonist
Tocris Bioscience
Discontinued Product
5789 has been discontinued. View all Free Fatty Acid Receptor Agonists products.

Key Product Details

Description

Potent FFA1 (GPR40) agonist
View all Free Fatty Acid Receptor Agonists »

Product Description

AM 4668 is a potent FFA1 (GPR40) agonist (EC50 = 3.6 nM in an IP3 assay in GPR40 transfected A9 cells). Inhibits insulin secretion from isolated pancreatic islets. Reduces blood glucose levels following oral glucose challenge in mice. Orally bioavailable.

Product Specifications for AM 4668

Molecular Weight

488.48

Formula

C24H19F3O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid

CAS Number

1011531-27-3

PubChem ID

24897670

InChI Key

BMLGZNVPWRUVNM-IBGZPJMESA-N

SMILES

CC1=C(COC2=CC=C(C=C2)[C@H](CC(O)=O)C2=NOC=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.85 100
Ethanol 48.85 100

Preparing Stock Solutions for AM 4668

The following data is based on the product molecular weight 488.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.05 mL 10.24 mL 20.47 mL
5 mM 0.41 mL 2.05 mL 4.09 mL
10 mM 0.20 mL 1.02 mL 2.05 mL
50 mM 0.04 mL 0.20 mL 0.41 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for AM 4668

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AM 4668

For research use only

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