Ambenonium dichloride
Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
Purity: ≥99%
Biological Activity
Ambenonium dichloride is an extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
-
Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities.
Hodge et al.
Mol.Pharmacol., 1992;41:937 -
Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors.
Bolognesi et al.
Farmaco, 2003;58:917 -
An investigation of the structure-activity correlations within a series of amben. analogs.
Lands et al.
J.Pharmacol.Exp.Ther., 1958;123:121 -
Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution.
Web
Biochim.Biophys.Acta., 1965;102:172
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for Ambenonium dichloride
The citations listed below are publications that use Tocris products. Selected citations for Ambenonium dichloride include:
2 Citations: Showing 1 - 2
-
Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
Authors: Mamaligas Et al.
Scientific Reports 2016;6:37834
-
Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
Authors: Shin Et al.
Int J Mol Sci 2015;112:8124
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for Ambenonium dichloride
There are currently no reviews for this product. Be the first to review Ambenonium dichloride and earn rewards!
Have you used Ambenonium dichloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
