Ambenonium dichloride

Key Product Details

Product Description

Ambenonium dichloride is an extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC₅₀ values are 0.000698 and 8.20 μM at AChE and BChE respectively).

Product Specifications for Ambenonium dichloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ambenonium dichloride

The following data is based on the product molecular weight 608.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.64 mL	8.22 mL	16.43 mL
5 mM	0.33 mL	1.64 mL	3.29 mL
10 mM	0.16 mL	0.82 mL	1.64 mL
50 mM	0.03 mL	0.16 mL	0.33 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

• Web Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 1965 PMID: 5833399
• Hodge Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 1992 PMID: 1588924
• Lands An investigation of the structure-activity correlations within a series of amben. analogs. J.Pharmacol.Exp.Ther. 1958 PMID: 13550066
• Bolognesi Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors. Farmaco 2003 PMID: 13679187

Product Documents for Ambenonium dichloride