Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
Biological ActivityExtremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities.
Hodge et al.
Design, synthesis and biological evaluation of amben. derivatives as AChE inhibitors.
Bolognesi et al.
An investigation of the structure-activity correlations within a series of amben. analogs.
Lands et al.
Affinity for benzoquinonium, and amben. derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution.
Citations for Ambenonium dichloride
The citations listed below are publications that use Tocris products. Selected citations for Ambenonium dichloride include:
2 Citations: Showing 1 - 2
Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
Authors: Mamaligas Et al.
Scientific Reports 2016;6:37834
Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
Authors: Shin Et al.
Int J Mol Sci 2015;112:8124
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