Catalog Number: 6043
Alternate Names: BML 284, CID 11210285
Chemical Name: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride
Biological Activity
Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A small-molecule agonist of the Wnt signaling pathway.
    Liu et al.
    Angew.Chem.Int.Ed.Engl., 2005;44:1987
  2. 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes.
    Wang et al.
    Inflamm.Res., 2016;65:61
  3. Tubulin is a molecular target of the Wnt-activating chemical probe.
    Fukuda et al.
    BMC Biochem., 2016;17:9
  4. Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage.
    Denicol et al.
    Sci.Rep., 2013;3:1266

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