Wnt canonical signaling activator. Also inhibits tubulin polymerization. Suppresses TLR2/4/5-induced inflammatory response in human monocytes. Inhibits cell proliferation and induces cell cycle arrest in MDA-MB-231 breast cancer cells. Also decreases embryo to blastocyst development.
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A small-molecule agonist of the Wnt signaling pathway.
Liu et al.
2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes.
Wang et al.
Tubulin is a molecular target of the Wnt-activating chemical probe.
Fukuda et al.
BMC Biochem., 2016;17:9
Canonical WNT signaling regulates development of bovine embryos to the blastocyst stage.
Denicol et al.