Chemical Name: (αS)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid
Biological ActivitySelective endothelin receptor ETA antagonist. Displays approximately 200-fold selectivity for ETA over ETB (Ki values are 1 nM and 195 nM for respectively). Prevents endothelin-induced sudden death in rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists.
Riechers et al.
Ambrisentan, a non-peptide endothelin receptor antagonist.
Vatter & Seifert
Cardiovasc.Drug Rev., 2006;24:63
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