Ambrisentan

Key Product Details

Product Description

Ambrisentan is a selective endothelin receptor ET_A antagonist. Displays approximately 200-fold selectivity for ET_A over ET_B (K_i values are 1 nM and 195 nM for respectively). Prevents endothelin-induced sudden death in rats.

Product Specifications for Ambrisentan

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ambrisentan

The following data is based on the product molecular weight 378.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.21 mL	26.43 mL
5 mM	0.53 mL	2.64 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Vatter & Seifert Ambrisentan, a non-peptide endothelin receptor antagonist. Cardiovasc.Drug Rev. 2006 PMID: 16939634
• Riechers Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. J.Med.Chem. 1996 PMID: 8667356

Product Documents for Ambrisentan