Chemical Name: (2E)-4-[(1R,5R,6R)-3-(1E)-1-Hepten-1-yl-5-hydroxy-4-(hydroxymethyl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-1-yl]-2-methyl-2-butenoic acid
Biological ActivityQuorum sensing inhibitor. Inhibits auto-inducing peptide (AIP) signal biosynthesis in MRSA (IC50 = 2.5 μM). Reduces MRSA-induced abcess formation in rats. Exhibits activity against pathogenic Gram-positive bacteria but not commensal bacteria.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Signal biosynthesis inhibition with ambuic acid as a strategy to target antibiotic-resistant infections.
Todd et al.
Antimicrob.Agents Chemother., 2017;61:e00263-17
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