AMG 18 hydrochloride
Chemical Name: 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride
Biological ActivityAMG 18 hydrochloride is a potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability.
Harrington et al.
ACS Med.Chem.Lett., 2014;6:68
Citation for AMG 18 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for AMG 18 hydrochloride include:
1 Citation: Showing 1 - 1
The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response.
Authors: Xu Et al.
JCI Insight 2019;4
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