AMG 18 hydrochloride
Chemical Name: 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride
Biological ActivityPotent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability.
Harrington et al.
ACS Med.Chem.Lett., 2014;6:68
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