AMG 18 hydrochloride

Tocris Bioscience | Catalog # 6166

Potent and selective IRE1α inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective IRE1α inhibitor
View all IRE1 Inhibitors »

Product Description

AMG 18 hydrochloride is a potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases.

Product Specifications for AMG 18 hydrochloride

Molecular Weight

637.58

Formula

C31H29ClN6O3S.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride

CAS Number

2250019-92-0

PubChem ID

134160238

InChI Key

CNWIPRHGMZTPSB-BOXHHOBZSA-N

SMILES

CC1=C(C2=C(C(NS(=O)(C3=C(C=CC=C3)Cl)=O)=CC=C2)C=C1)OC4=C(C5=NC(N[C@H]6CCCNC6)=NC=C5)C=CC=N4.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 63.76 100
DMSO 63.76 100

Preparing Stock Solutions for AMG 18 hydrochloride

The following data is based on the product molecular weight 637.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.57 mL 7.84 mL 15.68 mL
5 mM 0.31 mL 1.57 mL 3.14 mL
10 mM 0.16 mL 0.78 mL 1.57 mL
50 mM 0.03 mL 0.16 mL 0.31 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for AMG 18 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AMG 18 hydrochloride

For research use only

Citations for AMG 18 hydrochloride

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