Aminopotentidine
Discontinued Product
Chemical Name: 4-Amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]imino]methyl]amino]ethyl]benzamide
Purity: ≥97%
Biological Activity
Aminopotentidine is a H2 antagonist (KB values are 220 and 280 nM at human and guinea pig H2 receptors respectively) and precursor for the synthesis of the [125I]-iodo derivative.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.
Hirschfield et al.
J.Med.Chem., 1992;35:2231 -
Reversible and irreversible labeling and autoradiographic localisation of the cerebral histamine H2 receptor using [125I]iodinated probes.
Ruat et al.
Proc.Natl.Acad.Sci.USA, 1990;87:1658 -
Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine.
Xie et al.
Bioorg.Med.Chem.Lett., 2006;16:3886
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