Catalog Number: 0721
Chemical Name: 4-Amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]imino]methyl]amino]ethyl]benzamide
Biological Activity
H2 antagonist (KB values are 220 and 280 nM at human and guinea pig H2 receptors respectively) and precursor for the synthesis of the [125I]-iodo derivative.
Technical Data
  • M.Wt:
    477.6
  • Formula:
    C26H35N7O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    140873-26-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor.
    Hirschfield et al.
    J.Med.Chem., 1992;35:2231
  2. Reversible and irreversible labeling and autoradiographic localisation of the cerebral histamine H2 receptor using [125I]iodinated probes.
    Ruat et al.
    Proc.Natl.Acad.Sci.USA, 1990;87:1658
  3. Synthesis and pharmacological characterization of novel fluorescent histamine H2-receptor ligands derived from aminopotentidine.
    Xie et al.
    Bioorg.Med.Chem.Lett., 2006;16:3886

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