Chemical Name: 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
Biological ActivityAmitriptyline hydrochloride is an inhibitor of serotonin and noradrenaline uptake; also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity. Tricyclic antidepressant (TCA). Also a TrkA/B agonist. Induces neurite outgrowth in PC12 cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding.
Sanchez and Hyttel
Antidepressants as analgesics: an overview of central and peripheral mechanisms of action.
Sawynok et al.
J.Psychiatry Neurosci., 2001;26:21
Antinociception induced by amitript. and imipr. is mediated by α2A-adrenoceptors.
Ghelardini et al.
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