Amthamine dihydrobromide

Key Product Details

Product Description

Amthamine dihydrobromide is a highly selective H₂ agonist, slightly more potent than histamine itself. Only a weak antagonist at H₃ and has no activity at H₁ receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.

Product Specifications for Amthamine dihydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Amthamine dihydrobromide

The following data is based on the product molecular weight 319.06.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.67 mL	31.34 mL
5 mM	0.63 mL	3.13 mL	6.27 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 20 publications citing the usage of this product.

• Poli In vitro cardiac pharmacology of the new histamine H₂ receptor agonist amthamine; comparisons with histamine and dimaprit. Agents Actions 1993 PMID: 8147269
• Eriks Histamine H₂-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole. J.Med.Chem. 1992 PMID: 1507209
• Jarajapu Histamine decreases myogenic tone in rat cerebral arteries by H₂-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP. Eur.J.Pharmacol. 2006 PMID: 16920098
• Coruzzi The new potent and selective histamine H₂ receptor agonist amthamine as a tool to study gastric secretion. Naunyn Schmiedebergs Arch.Pharmacol. 1993 PMID: 8377843

Product Documents for Amthamine dihydrobromide