Catalog Number: 0668
Chemical Name: 2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
Biological Activity
Highly selective H2 agonist, slightly more potent than histamine itself. Only a weak antagonist at H3 and has no activity at H1 receptors. Induces vasodilation of cerebral arteries and decreases myogenic tone in vitro.
Technical Data
  • M.Wt:
    319.06
  • Formula:
    C6H11N3S.2HBr
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    142457-00-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Histamine H2-receptor agonists. Synthesis, in vitro pharmacology, and qualitative structure-activity relationships of substituted 4- and 5-(2-aminoethyl)thiazole.
    Eriks et al.
    J.Med.Chem., 1992;35:3239
  2. Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated Kv channel activation, independent of endothelium and cyclic AMP.
    Jarajapu et al.
    Eur.J.Pharmacol., 2006;547:116
  3. The new potent and selective histamine H2 receptor agonist amthamine as a tool to study gastric secretion.
    Coruzzi et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1993;348:77
  4. In vitro cardiac pharmacology of the new histamine H2 receptor agonist amthamine; comparisons with histamine and dimaprit.
    Poli et al.
    Agents Actions, 1993;40:44
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Amthamine dihydrobromide include:

2 Citations: Showing 1 - 2
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  1. Histamine H2 receptor signaling � environment interactions determine susceptibility to experimental allergic encephalomyelitis.
    Authors: Saligrama Et al.
    FASEB J 2014;28:1898
  2. Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation.
    Authors: Copsel Et al.
    J Biol Chem 2011;286:6979

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