Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors (pEC50
values are 7.06-9.50 at hCTa
, 8.11 at rCTa
, 7.73-10.1 at hAMY1a
, 9.74 at rAMY1a
, 7.92 at hAMY1b
, 7.78-9.9 at hAMY2a
, 7.94 at hAMY2b
, 8.09-10.8 at hAMY3a
, 9.97 at rAMY and 8.19 at hAMY3b
) receptors. Suppresses insulin-stimulated glucose uptake. Delays gastric emptying and promotes satiety. Active in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development.
Bower and Hay