Catalog Number: 3388
Alternate Names: ZD1033
Chemical Name: α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Biological Activity
Potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes only under agreement from AstraZeneca
Background References
  1. The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor.
    Dukes et al.
    J.Steroid Biochem.Mol.Biol., 1996;58:439
  2. Anastrozole: a new selective nonsteroidal aromatase inhibitor.
    Goss and Tye
    Oncology, 1997;11:1697
  3. Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting?
    Br.J.Cancer, 2001;85:6
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