Chemical Name: α1,α1,α3,α3-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Biological ActivityAnastrozole is a potent and highly selective aromatase (CYP19) inhibitor (IC50 = 15 nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo. Orally active.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor.
Dukes et al.
J.Steroid Biochem.Mol.Biol., 1996;58:439
Anastrozole: a new selective nonsteroidal aromatase inhibitor.
Goss and Tye
Anastrozole (ArimidexTM) - an aromatase inhibitor for the adjuvant setting?
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