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Angiopep-2-Cys

Catalog #: 8902 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8902/5
Angiopep-2-Cys
1 Image
Description: Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

Purity: ≥95%

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Biological Activity

Angiopep-2-Cys is a synthetic peptide able to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1) receptors present on brain endothelial cells and neurons. Angiopep-2-Cys is a conjugate of Angiopep-2 (Cat. No. 8828) and Cystein, and can be used to functionalize LNPs via thiol-maleimide click chemistry to target LRP1 receptors present on blood-brain barrier (BBB). mRNA LNPs functionalized with Angiopep-2-Cys shows improved transfection efficiency in cultured brain endothelial and neuronal cells, and in vivo, after systemic administration in mice.

Technical Data

M.Wt:
2404.64
Formula:
C107H154N30O32S
Sequence:
TFFYGGSRGKRNNFKTEEYC
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
906480-09-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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