Nootropic, with modulatory actions through allosteric potentiation of AMPA specific receptors, reduction of glutamate receptor desensitization and potentiation of metabotropic glutamate receptor activity. Anxiolytic following systemic administration.
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Aniracetam reduces glutamate receptor desensitisation and slows the decay of fast excitatory synaptic currents in the hippocampus.
Isaacson and Nicholl
Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.
Ito et al.
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Nakamura and Kurasawa