Anisomycin

  ( 17 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1290
Chemical Name:(2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate
Product Details
Citations (17)
Reviews
Biological Activity
Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
Technical Data
  • M.Wt:
    265.31
  • Formula:
    C14H19NO4
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    22862-76-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Anisomycin include:

17 Citations: Showing 1 - 10
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  1. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Authors: Li
    Proc Natl Acad Sci U.S.A.  2017;114(21):5527
  2. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    Neurobiol Dis  2015;35:308
  3. Direct visualization of newly synthesized target proteins in situ.
    Authors: Dieck Et al.
    Nat Methods  2015;12:411
  4. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One  2014;8:e83941
  5. Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
    Authors: Dobrikov Et al.
    Mol Cell Biol  2014;34:439
  6. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses.
    Authors: Valentine Et al.
    Cell Microbiol  2014;16:1
  7. Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.
    Authors: Basu Et al.
    Autophagy  2014;10:1193
  8. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    Autophagy  2013;59:42736
  9. Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
    Authors: Ma Et al.
    Nat Neurosci  2013;16:1299
  10. Metabolic labeling with noncanonical amino acids and visualization by chemoselective fluorescent tagging.
    Authors: Dieck Et al.
    Curr Protoc Cell Biol  2012;Chapter 7:Unit7.11
  11. On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
    Authors: Gouet Et al.
    PLoS One  2012;7:e49293
  12. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci  2012;32:8127
  13. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    J Neurosci  2011;31:725
  14. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
    Authors: Hays Et al.
    J Neurosci  2011;31:14223
  15. Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
    Authors: Fuortes Et al.
    Epilepsia  2010;51:1633
  16. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  17. BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.
    Authors: Zhong Et al.
    J Neurosci  2009;29:9977
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Average Rating: 5 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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