Anisomycin

Catalog # Availability Size / Price Qty
1290/10
1290/50
JNK/c-jun Activators Small Molecule
1 Image
Description: JNK, SAPK and p38 activator

Chemical Name: (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate

Purity: ≥98%

Product Details
Citations (19)
Reviews (1)

Biological Activity

Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).

Technical Data

M.Wt:
265.31
Formula:
C14H19NO4
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
22862-76-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Anisomycin

The citations listed below are publications that use Tocris products. Selected citations for Anisomycin include:

19 Citations: Showing 1 - 10

  1. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Authors: Li
    Proc Natl Acad Sci U.S.A.  2017;114(21):5527
  2. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    Neurobiol Dis  2015;35:308
  3. Direct visualization of newly synthesized target proteins in situ.
    Authors: Dieck Et al.
    Nat Methods  2015;12:411
  4. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One  2014;8:e83941
  5. Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
    Authors: Dobrikov Et al.
    Mol Cell Biol  2014;34:439
  6. Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses.
    Authors: Valentine Et al.
    Cell Microbiol  2014;16:1
  7. Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.
    Authors: Basu Et al.
    Autophagy  2014;10:1193
  8. Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression.
    Authors: Ramiro-Cortés
    PLoS One  2013;8:e71155
  9. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    Autophagy  2013;59:42736
  10. Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
    Authors: Ma Et al.
    Nat Neurosci  2013;16:1299
  11. Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
    Authors: Liu Et al.
    J Neurophysiol  2013;110:505
  12. Metabolic labeling with noncanonical amino acids and visualization by chemoselective fluorescent tagging.
    Authors: Dieck Et al.
    Curr Protoc Cell Biol  2012;Chapter 7:Unit7.11
  13. On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
    Authors: Gouet Et al.
    PLoS One  2012;7:e49293
  14. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci  2012;32:8127
  15. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    J Neurosci  2011;31:725
  16. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
    Authors: Hays Et al.
    J Neurosci  2011;31:14223
  17. Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
    Authors: Fuortes Et al.
    Epilepsia  2010;51:1633
  18. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  19. BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.
    Authors: Zhong Et al.
    J Neurosci  2009;29:9977

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Increase p38 MAPK activity
By Anonymous on 11/02/2017
Species: Rat

We use anisomycin to increrase p38 MAPK activity, though it can also be used to block protein synthesis.


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