Chemical Name: (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate
Biological ActivityProtein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.
Cano et al.
The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
Croons et al.
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.
Hazzalin et al.
The stress-activated protein kinase subfamily of c-Jun kinases.
Kyriakis et al.
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun.
Sanchez et al.
Citations for Anisomycin
The citations listed below are publications that use Tocris products. Selected citations for Anisomycin include:
21 Citations: Showing 1 - 10
Genetic reduction of eEF2 kinase alleviates pathophysiology in Alzheimer's disease model mice.
Authors: Beckelman Et al.
J Clin Invest 2019;129:820
Enhanced Glycolysis Supports Cell Survival in EGFR-Mutant Lung Adenocarcinoma by Inhibiting Autophagy-Mediated EGFR Degradation.
Authors: Kim Et al.
Cancer Res 2018;78:4482
Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
Proc Natl Acad Sci U.S.A. 2017;114(21):5527
Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
Authors: Zhao Et al.
Neurobiol Dis 2015;35:308
Direct visualization of newly synthesized target proteins in situ.
Authors: Dieck Et al.
Nat Methods 2015;12:411
SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
Authors: Wang Et al.
PLoS One 2014;8:e83941
Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
Authors: Dobrikov Et al.
Mol Cell Biol 2014;34:439
Small molecule screen yields inhibitors of Pseudomonas homoserine lactone-induced host responses.
Authors: Valentine Et al.
Cell Microbiol 2014;16:1
Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.
Authors: Basu Et al.
Long lasting protein synthesis- and activity-dependent spine shrinkage and elimination after synaptic depression.
PLoS One 2013;8:e71155
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
Authors: Bernard Et al.
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
Authors: Ma Et al.
Nat Neurosci 2013;16:1299
Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings.
Authors: Liu Et al.
J Neurophysiol 2013;110:505
Metabolic labeling with noncanonical amino acids and visualization by chemoselective fluorescent tagging.
Authors: Dieck Et al.
Curr Protoc Cell Biol 2012;Chapter 7:Unit7.11
On the mechanism of synaptic depression induced by CaMKIIN, an endogenous inhibitor of CaMKII.
Authors: Gouet Et al.
PLoS One 2012;7:e49293
Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
Authors: Fortin Et al.
J Neurosci 2012;32:8127
Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
Authors: Zhao Et al.
J Neurosci 2011;31:725
Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
Authors: Hays Et al.
J Neurosci 2011;31:14223
Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
Authors: Fuortes Et al.
Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
Authors: Huang Et al.
J Neurosci 2010;30:6080
BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.
Authors: Zhong Et al.
J Neurosci 2009;29:9977
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We use anisomycin to increrase p38 MAPK activity, though it can also be used to block protein synthesis.