Catalog Number: 1290
Chemical Name: (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate
Biological Activity
Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
Technical Data
  • M.Wt:
    265.31
  • Formula:
    C14H19NO4
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    22862-76-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.
    Cano et al.
    Mol.Cell.Biol., 1994;14:7352
  2. Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.
    Hazzalin et al.
    Mol.Cell.Biol., 1998;18:1844
  3. The stress-activated protein kinase subfamily of c-Jun kinases.
    Kyriakis et al.
    Nature, 1994;369:156
  4. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun.
    Sanchez et al.
    Nature, 1994;372:794
  5. The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
    Croons et al.
    J.Pharmacol.Exp.Ther., 2009;329:856
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Anisomycin include:

11 Citations: Showing 1 - 10
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  1. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Authors: Li
    Proc Natl Acad Sci U.S.A. 2017;114(21):5527
  2. Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    Neurobiol Dis 2015;35:308
  3. Direct visualization of newly synthesized target proteins in situ.
    Authors: Dieck Et al.
    Nat Methods 2015;12:411
  4. SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks.
    Authors: Wang Et al.
    PLoS One 2014;8:e83941
  5. Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells.
    Authors: Basu Et al.
    Autophagy 2014;10:1193
  6. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
    Authors: Bernard Et al.
    Autophagy 2013;59:42736
  7. Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
    Authors: Ma Et al.
    Nat Neurosci 2013;16:1299
  8. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci 2012;32:8127
  9. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry.
    Authors: Hays Et al.
    J Neurosci 2011;31:14223
  10. Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation.
    Authors: Fuortes Et al.
    Epilepsia 2010;51:1633
  11. BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.
    Authors: Zhong Et al.
    J Neurosci 2009;29:9977
Expand to show all 11 Citations
Average Rating: 5 (Based on 1 review)

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