Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).
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Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.
Cano et al.
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction.
Hazzalin et al.
The stress-activated protein kinase subfamily of c-Jun kinases.
Kyriakis et al.
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun.
Sanchez et al.
The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
Croons et al.
The citations listed below are publications that use Tocris products. Selected citations for Anisomycin include:
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