Chemical Name: 3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
Biological ActivityOligomeric aggregation inhibitor. Inhibits formation of pathological prion protein (PrPSc) and α-synuclein aggregates in vitro. Prevents accumulation of PrPSc in brain and spleen, and prolongs survival of prion-infected mice. Exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model. Orally bioavailable and brain penetrant.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease.
Wagner et al.
Acta Neuropathol., 2013;125:795
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