Antagonist G

Catalog # Availability Size / Price Qty
1954/1
Antagonist G
1 Image
Description: Broad spectrum neuropeptide receptor antagonist
Alternative Names: [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11)
Product Details
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Biological Activity

Substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo.

Technical Data

M.Wt:
951.2
Formula:
C49H66N12O6S
Sequence:
RWFWLM

(Modifications: Trp-2 = D-Trp, Phe-3 = N-Methyl-Phe, Trp-5 = D-Trp, Met-7 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
115150-59-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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