Antagonist G

Tocris Bioscience | Catalog # 1954

Broad spectrum neuropeptide receptor antagonist
Tocris Bioscience
Discontinued Product
1954 has been discontinued. View all Tachykinin Antagonists products.

Key Product Details

Description

Broad spectrum neuropeptide receptor antagonist

Alternative Names

[Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11)
View all Tachykinin Antagonists »

Product Description

Antagonist G is a substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo.

Product Specifications for Antagonist G

Molecular Weight

951.20

Formula

C49H66N12O6S

Storage

Desiccate at -20°C

CAS Number

115150-59-9

PubChem ID

163960

InChI Key

CUCSSYAUKKIDJV-FAXBSAIASA-N

SMILES

[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product.

Product Documents for Antagonist G

Certificate of Analysis

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Product Specific Notices for Antagonist G

For research use only

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