Biological ActivityAntagonist G is a substance P analog that is a broad spectrum neuropeptide antagonist and antiproliferative agent. Blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. Inhibits neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro; activates JNK and stimulates apoptosis. Inhibits growth of SCLC xenografts in mice in vivo.
(Modifications: Trp-2 = D-Trp, Phe-3 = N-Methyl-Phe, Trp-5 = D-Trp, Met-7 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Broad spectrum neuropeptide antagonists inhibit the growth of small cell lung cancer in vivo.
Langdon et al.
Cancer Res., 1992;52:4554
[Arg6, D-Trp7,9, NmePhe8]-Substance P (6-11) (antagonist G) induces AP-1 transcription and sensitizes cells to chemotherapy.
MacKinnon et al.
A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro.
Woll and Rozengurt
Cancer Res., 1990;50:3968
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