AP 14145 hydrochloride

Catalog # Availability Size / Price Qty
6481/5
AP 14145 hydrochloride | Ca2+-Activated Potassium Channel Modulators
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Description: KCa2 channel negative allosteric modulator

Chemical Name: N-[2-[[(1R)-1-[3-(Trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-7-yl]acetamide hydrochloride

Purity: ≥98%

Product Details
Reviews

Biological Activity

KCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.

Technical Data

M.Wt:
398.81
Formula:
C18H17F3N4O.HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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