AP 14145 hydrochloride

Key Product Details

Product Description

AP 14145 hydrochloride is a K_Ca2 (small conductance Ca²⁺-activated potassium) channel negative allosteric modulator (IC₅₀ = 1.1 μM). Increases the EC₅₀ of Ca²⁺ on K_Ca2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.

Product Specifications for AP 14145 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AP 14145 hydrochloride

The following data is based on the product molecular weight 398.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.54 mL	25.07 mL
5 mM	0.50 mL	2.51 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Simó-Vicens A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (K_Ca2) channels. Br.J.Pharmacol. 2017 PMID: 28925012
• Diness Termination of vernakalant-resistant atrial fibrillation by inhibition of small-conductance Ca²⁺-activated K⁺ channels in pigs. Circ.Arrhythm.Electrophysiol. 2017 PMID: 29018164

Product Documents for AP 14145 hydrochloride