AP 14145 hydrochloride
Chemical Name: N-[2-[[(1R)-1-[3-(Trifluoromethyl)phenyl]ethyl]amino]-1H-benzimidazol-7-yl]acetamide hydrochloride
Biological ActivityKCa2 (small conductance Ca2+-activated potassium) channel negative allosteric modulator (IC50 = 1.1 μM). Increases the EC50 of Ca2+ on KCa2.3 channels by ~3-fold. Prolongs atrial effective refractory period (AERP) in rats. Reduces atrial fibrillation (AF) duration and prolongs atrial refractoriness without affecting ventricular refractory period in an animal AF model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Termination of vernakalant-resistant atrial fibrillation by inhibition of small-conductance Ca2+-activated K+ channels in pigs.
Diness et al.
A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa2) channels.
Simó-Vicens et al.
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