Chemical Name: 4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime
Biological ActivityAP 18 is a reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC50 = 10.3 μM for the inhibition of Yo-Pro uptake).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.
Petrus et al.
Pore dilation occurs in TRPA1 but not in TRPM8 channels.
Chen et al.
Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.
Taylor-Clark et al.
Citations for AP 18
The citations listed below are publications that use Tocris products. Selected citations for AP 18 include:
2 Citations: Showing 1 - 2
Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice.
Authors: Izzo Et al.
Br J Pharmacol 2012;166:1444
Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.
Authors: Capasso Et al.
Br J Pharmacol 2012;165:1966
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