Reversible TRPA1 channel blocker (IC50
values are 3.1 and 4.5 μ
M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo
. Also blocks TRPA1 pore dilation (IC50
= 10.3 μ
M for the inhibition of Yo-Pro uptake).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition.
Petrus et al.
Pore dilation occurs in TRPA1 but not in TRPM8 channels.
Chen et al.
Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1.
Taylor-Clark et al.