Chemical Name:4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime
Biological Activity Reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC50 = 10.3 μM for the inhibition of Yo-Pro uptake).
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C
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