AP 18

Catalog # Availability Size / Price Qty
3296/10
3296/50
AP 18 | CAS No. 55224-94-7 | TRPA1 Blockers
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Description: Reversible TRPA1 channel blocker

Chemical Name: 4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime

Purity: ≥98%

Product Details
Citations (2)
Reviews

Biological Activity

Reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC50 = 10.3 μM for the inhibition of Yo-Pro uptake).

Technical Data

M.Wt:
209.67
Formula:
C11H12ClNO
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
55224-94-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for AP 18

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