AP 18

  ( 1 citations )    
Product Datasheet
Catalog Number:3296
Chemical Name:4-(4-Chlorophenyl)-3-methyl-3-buten-2-one oxime
Product Details
Citations (1)
Reviews
Biological Activity
Reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC50 = 10.3 μM for the inhibition of Yo-Pro uptake).
Technical Data
  • M.Wt:
    209.67
  • Formula:
    C11H12ClNO
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    55224-94-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for AP 18 include:

1 Citations: Showing 1 - 1

  1. Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.
    Authors: Capasso Et al.
    Br J Pharmacol  2012;165:1966

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