AP 1903

Key Product Details

Product Description

AP 1903 is a chemical protein dimerizer for use in FKBP fusion protein systems. Induces apoptosis in cells expressing a fusion protein consisting of FKBP^F36V and intracellular domain of Fas receptor with high potency (EC₅₀ = 0.1 nM). Exhibits >50-fold selectivity for FKBP^F36V-Fas fusion protein over wild-type FKBP. Also induces apoptosis in cells expressing Cas9-FK506 fusion proteins, in inducible caspase 9 (iCas9) suicide gene system. Active in vivo.

Product Specifications for AP 1903

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AP 1903

The following data is based on the product molecular weight 1411.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	0.71 mL	3.54 mL	7.08 mL
5 mM	0.14 mL	0.71 mL	1.42 mL
10 mM	0.07 mL	0.35 mL	0.71 mL
50 mM	0.01 mL	0.07 mL	0.14 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Gargett & Brown The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells. Front.Pharmacol. 2014 PMID: 25389405
• Clackson Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc.Natl.Acad.Sci.USA. 1998 PMID: 9724721

Product Documents for AP 1903