AP 20187

Tocris Bioscience | Catalog # 6297

Chemical inducer of protein dimerization; active in vivo
Tocris Bioscience

Key Product Details

Description

Chemical inducer of protein dimerization; active in vivo
View all Protein Dimerizers »

Product Description

AP 20187 is a chemical inducer of dimerization (CID) for use in FKBP fusion protein systems. Induces apoptosis in cells expressing fusion proteins consisting of FKBPF36V and the intracellular domain of the Fas receptor, Fas-associated death domain (FADD) or a caspase. Selective for FKBPF36V-Fas fusion proteins over wild-type FKBP. Induces apoptosis of senescent cells expressing caspase-8-FKBP fusion proteins under the control of an Ink4a promoter. Active in vivo.

For more information about how AP 20187 may be used, see our protocol.

Product Specifications for AP 20187

Molecular Weight

1482.77

Formula

C82H107N5O20

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,2'-[[2-[(Dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]

CAS Number

195514-80-8

PubChem ID

78357784

InChI Key

NSBGUMKAXUXKGI-BPNHAYRBSA-N

SMILES

O=C([C@@H]1CCCCN1C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)O[C@@H](C3=CC(OCC(NCC(CN(C)C)CNC(COC4=CC=CC([C@H](OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)CCC7=CC(OC)=C(OC)C=C7)=C4)=O)=O)=CC=C3)CCC8=CC(OC)=C(OC)C=C8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 148.28 100
Ethanol 148.28 100

Preparing Stock Solutions for AP 20187

The following data is based on the product molecular weight 1482.77.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.67 mL 3.37 mL 6.74 mL
5 mM 0.13 mL 0.67 mL 1.35 mL
10 mM 0.07 mL 0.34 mL 0.67 mL
50 mM 0.01 mL 0.07 mL 0.13 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for AP 20187

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AP 20187

For research use only

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