Chemical Name: 2,2'-[[2-[(Dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]
Biological ActivityAP 20187 is a chemical inducer of dimerization (CID) for use in FKBP fusion protein systems. Induces apoptosis in cells expressing fusion proteins consisting of FKBPF36V and the intracellular domain of the Fas receptor, Fas-associated death domain (FADD) or a caspase. Selective for FKBPF36V-Fas fusion proteins over wild-type FKBP. Induces apoptosis of senescent cells expressing caspase-8-FKBP fusion proteins under the control of an Ink4a promoter. Active in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins.
Jacobs et al.
Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer.
Shariat et al.
Cancer Res., 2001;61:2562
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan.
Baker et al.
Exposure to sequestered self-antigens in vivo is not sufficient for the induction of autoimmune diabetes.
PLoS One, 2017;12:e0173176
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for AP 20187
There are currently no reviews for this product. Be the first to review AP 20187 and earn rewards!
Have you used AP 20187?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image