Catalog Number: 5498
Biological Activity
High affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.
Technical Data
  • M.Wt:
    915.1
  • Formula:
    C46H66N12O8
  • Sequence:
    RIDR

    (Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    124833-45-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.
    Veale et al.
    Bioorg.Med.Chem.Lett., 2000;10:1949
  2. Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation.
    William et al.
    Am.J.Physiol.Cell Physiol., 2008;294:C1067
  3. Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development.
    Becker et al.
    Development, 2014;141:335

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