AP 811

Catalog # Availability Size / Price Qty
5498/1
Cat.No. 5498 - AP 811 | N2-[4-(2-Naphthoylamino)phenylacetyl]-Arg-Ile-Asp-Arg-(S)-2-methylbutylamide | CAS No. 124833-45-0
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Description: High affinity, selective NPR3 antagonist
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Biological Activity

High affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro.

Technical Data

M.Wt:
915.1
Formula:
C46H66N12O8
Sequence:
RIDR

(Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenylacetyl], Arg-4 = C-terminal (S)-2-methylbutylamide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
124833-45-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Good NPR3 agonist
By Anonymous on 07/12/2018
Species: Rat

Investigation of NPR3 agonism in blood vessels.


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