Biological ActivityEndogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Apelin peptides block the entry of human immunodeficiency virus (HIV).
Zou et al.
FEBS Lett., 2000;473:15
Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin.
Medhurst et al.
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Tatemoto et al.
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