Biological ActivityApelin-36 (human) is an endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Apelin peptides block the entry of human immunodeficiency virus (HIV).
Zou et al.
FEBS Lett., 2000;473:15
Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin.
Medhurst et al.
Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
Tatemoto et al.
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