Aphidicolin

Catalog # Availability Size / Price Qty
5736/1

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Aphidicolin | CAS No. 38966-21-1 | RNA/DNA Polymerase Inhibitors
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Description: DNA polymerase α, δ and ε inhibitor

Chemical Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol

Product Details
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Biological Activity

Aphidicolin is a DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.

Technical Data

M.Wt:
338.48
Formula:
C20H34O4
Solubility:
Soluble to 25 mM in DMSO
Storage:
Store at -20°C
CAS No:
38966-21-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Control of DNA replication and cell proliferation in eukaryotes by aphidicolin.
    Spadari et al.
    Toxicol.Pathol., 1984;12:143
  2. Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola.
    Bucknall et al.
    Antimicrob.Agents Chemother., 1973;4:294
  3. DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells.
    Syväoja et al.
    Proc.Natl.Acad.Sci.U.S.A., 1990;87:6664

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