Catalog Number: 5736
Chemical Name: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-Tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol
Biological Activity
DNA polymerase α, δ and ε inhibitor. Exhibits selectivity over DNA polymerase β and γ. Antimitotic, antibiotic and antiviral.
Technical Data
  • M.Wt:
    338.48
  • Formula:
    C20H34O4
  • Solubility:
    Soluble to 25 mM in DMSO
  • Storage:
    Store at -20°C
  • CAS No:
    38966-21-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Control of DNA replication and cell proliferation in eukaryotes by aphidicolin.
    Spadari et al.
    Toxicol.Pathol., 1984;12:143
  2. Antiviral effects of aphidicolin, a new antibiotic produced by Cephalosporium aphidicola.
    Bucknall et al.
    Antimicrob.Agents Chemother., 1973;4:294
  3. DNA polymerases α, δ, and ε: three distinct enzymes from HeLa cells.
    Syväoja et al.
    Proc.Natl.Acad.Sci.U.S.A., 1990;87:6664

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