API-1

Tocris Bioscience | Catalog # 3897

Selective Akt/PKB inhibitor. Antitumor
Tocris Bioscience
Discontinued Product
3897 has been discontinued. View all Akt (Protein Kinase B) Inhibitors products.

Key Product Details

Description

Selective Akt/PKB inhibitor. Antitumor
View all Akt (Protein Kinase B) Inhibitors »

Product Description

API-1 is an Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.

Product Specifications for API-1

Molecular Weight

337.29

Formula

C13H15N5O6

Storage

Store at RT

Purity

≥96% (HPLC)

Chemical Name

4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide

CAS Number

36707-00-3

PubChem ID

24773090

InChI Key

SPBWHPXCWJLQRU-FITJORAGSA-N

SMILES

O[C@@H]1[C@@H](CO)O[C@@H](N2C(N=CN=C3N)=C3C(C(C(N)=O)=C2)=O)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.73 100

Preparing Stock Solutions for API-1

The following data is based on the product molecular weight 337.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.82 mL 29.65 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
10 mM 0.30 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.30 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for API-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for API-1

For research use only

Customer Reviews for API-1 (1)

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  • Study of API-1 induction c-FLIP degradation and synergization with TRAIL to augment apoptosis
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 01/16/2020
    Study of API-1 induction c-FLIP degradation and synergization with TRAIL to augment apoptosis.API-1 effectively induced apoptosis in tested cancer cell lines including activation of caspase-8 and caspase-9.
    API-1 3897

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