Catalog Number: 3897
Chemical Name: 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide
Biological Activity
Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitro and in vivo.
Technical Data
  • M.Wt:
    337.29
  • Formula:
    C13H15N5O6
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >96%
  • Storage:
    Store at RT
  • CAS No:
    36707-00-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.
    Kim et al.
    J.Biol.Chem., 2010;285:8383
Citations:

The citations listed below are publications that use Tocris products. Selected citations for API-1 include:

3 Citations: Showing 1 - 3
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  1. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2(TRKB) signaling in the adult human exocrine pancreas.
    Authors: Shamblott Et al.
    Cell Communication and Signaling 2016;14:23
  2. Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas
    Authors: Shamblott Et al.
    Cell Communication and Signaling 2016;14:23
  3. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells.
    Authors: Zhu Et al.
    EMBO J 2012;31:31

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