Apoptosis Activator 2
Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
Biological ActivityApoptosis Activator 2 is an apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Elevtaed p75NTR expression causes death of engrailed-deficient midbrain DArgic neurons by Erk1/2 suppression.
Alavian et al.
Neural Dev., 2009;4:11
Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones.
Jayaraman and Pike
Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
Nguyen and Wells
Citations for Apoptosis Activator 2
The citations listed below are publications that use Tocris products. Selected citations for Apoptosis Activator 2 include:
2 Citations: Showing 1 - 2
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.
Authors: Pan Et al.
Cell Res 2016;26:190
Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.
Authors: Stankiewicz Et al.
PLoS One 2005;280:38729
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Apoptosis Activator 2
Average Rating: 5 (Based on 1 Review)
Have you used Apoptosis Activator 2?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Apoptosis Activator 2 was used to induce apoptosis in epidermal cancer cell line.Works great and gives publishable outcome.