Apoptosis Activator 2

Catalog # Availability Size / Price Qty
Apoptosis Activator 2 | CAS No. 79183-19-0 | Apoptosis Inducer Compounds
1 Image
Description: Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione

Purity: ≥99%

Product Details
Citations (2)

Biological Activity

Apoptosis Activator 2 is an apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).

Technical Data

Soluble to 5 mM in ethanol and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Elevtaed p75NTR expression causes death of engrailed-deficient midbrain DArgic neurons by Erk1/2 suppression.
    Alavian et al.
    Neural Dev., 2009;4:11
  2. Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones.
    Jayaraman and Pike
    J.Neuroendocrinol., 2009;21:77
  3. Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
    Nguyen and Wells
    Proc.Natl.Acad.Sci.USA, 2003;100:7533

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Apoptosis Activator 2

The citations listed below are publications that use Tocris products. Selected citations for Apoptosis Activator 2 include:

2 Citations: Showing 1 - 2


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Apoptosis Activator 2

There are currently no reviews for this product. Be the first to review Apoptosis Activator 2 and earn rewards!

Have you used Apoptosis Activator 2?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.