Apoptosis Activator 2

  ( 2 citations )    
Product Datasheet
Catalog Number:2098
Chemical Name:1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
Product Details
Citations (2)
Reviews
Biological Activity
Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).
Technical Data
  • M.Wt:
    306.14
  • Formula:
    C15H9Cl2NO2
  • Solubility:
    Soluble to 5 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    79183-19-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Apoptosis Activator 2 include:

2 Citations: Showing 1 - 2
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  1. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2.
    Authors: Pan Et al.
    Cell Res  2016;26:190
  2. Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.
    Authors: Stankiewicz Et al.
    PLoS One  2005;280:38729

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