Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
Biological Activity Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).
Soluble to 5 mM in ethanol and to 100 mM in DMSO
Store at RT
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