Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50
= 4 - 9 μ
M for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50
> 40 μ
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Elevtaed p75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.
Alavian et al.
Neural Dev., 2009;4:11
Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones.
Jayaraman and Pike
Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
Nguyen and Wells
The citations listed below are publications that use Tocris products. Selected citations for Apoptosis Activator 2 include:
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