Apoptosis Activator 2

Tocris Bioscience | Catalog # 2098

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
Tocris Bioscience

Key Product Details

Description

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis
View all Apoptosis Inducer Compounds »

Product Description

Apoptosis Activator 2 is an apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).

Product Specifications for Apoptosis Activator 2

Molecular Weight

306.14

Formula

C15H9Cl2NO2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione

CAS Number

79183-19-0

PubChem ID

1901244

InChI Key

KGRJPLRFGLMQMV-UHFFFAOYSA-N

SMILES

ClC1=CC=C(CN2C(=O)C(=O)C3=CC=CC=C23)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.61 100
Ethanol 1.53 5

Preparing Stock Solutions for Apoptosis Activator 2

The following data is based on the product molecular weight 306.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.27 mL 16.33 mL 32.66 mL
5 mM 0.65 mL 3.27 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.27 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for Apoptosis Activator 2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Apoptosis Activator 2

For research use only

Citations for Apoptosis Activator 2

Customer Reviews for Apoptosis Activator 2 (1)

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  • Apoptosis Activator 2 was used to induce apoptosis in epidermal cancer cell line: Works ideally
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 02/13/2019
    Apoptosis Activator 2 was used to induce apoptosis in epidermal cancer cell line.Works great and gives publishable outcome.
    Apoptosis Activator 2 2098

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