Catalog Number: 2098
Chemical Name: 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
Biological Activity
Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).
Technical Data
  • M.Wt:
    306.14
  • Formula:
    C15H9Cl2NO2
  • Solubility:
    Soluble to 5 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    79183-19-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Elevtaed p75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.
    Alavian et al.
    Neural Dev., 2009;4:11
  2. Progesterone attenuates oestrogen neuroprotection via downregulation of oestrogen receptor expression in cultured neurones.
    Jayaraman and Pike
    J.Neuroendocrinol., 2009;21:77
  3. Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
    Nguyen and Wells
    Proc.Natl.Acad.Sci.USA, 2003;100:7533
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Apoptosis Activator 2 include:

1 Citations: Showing 1 - 1

  1. Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation.
    Authors: Stankiewicz Et al.
    PLoS One 2005;280:38729

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