Human APRIL/TNFSF13 ELISA Kit (Colorimetric)

Novus Biologicals | Catalog # NBP3-43451

Novus Biologicals
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Key Product Details

Sample Type & Volume Required Per Well

cell culture supernatants, serum and plasma (EDTA, heparin or citrate)
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Product Specifications

Assay Type

Sandwich ELISA

Kit Type

ELISA Kit (Colorimetric)

Species

Human

Specificity

This ELISA is specific for the measurement of natural and recombinant human APRIL. Detection of APRIL (human) in biological fluids by this ELISA kit is abolished in the presence of a APRIL receptor such as TACI:Fc (AG-40B-0079).

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Storage of components varies. See protocol for specific instructions.

Background: APRIL/TNFSF13

TNFSF13 is a proliferation-inducing ligand (APRIL), also designated TNFSF13, is a Type II membrane protein that shares characteristics with other members of the tumor necrosis factor (TNF) cytokine family. APRIL is expressed in high levels in transformed cell lines and in human colon, thyroid, and lymphoid tumor tissues. APRIL is critically involved in the regulation of infections, inflammation, autoimmune diseases, and tissue homeostasis. APRIL is implicated in the regulation of tumor cell growth. The C-terminal extracellular domain has b jelly roll topography and is important in ligand trimerization. The binding of the ligand to its respective receptor induces oligomerization, initiating downstream signaling events. Intrinsic to oligomerization is the formation of the receptor binding site at the junction between neighboring subunits, creating a multivalent ligand.

Long Name

A Proliferation-inducing Ligand

Alternate Names

CD256, TALL2, TNFSF13, TRDL1, ZTNF2

Gene Symbol

TNFSF13

Additional APRIL/TNFSF13 Products

Product Documents for Human APRIL/TNFSF13 ELISA Kit (Colorimetric)

Certificate of Analysis

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Product Specific Notices for Human APRIL/TNFSF13 ELISA Kit (Colorimetric)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

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