Aprotinin

Tocris Bioscience | Catalog # 4139

Competitive serine protease inhibitor
Tocris Bioscience

Key Product Details

Description

Competitive serine protease inhibitor
View all Additional Synthetic Protease Inhibitors »

Product Description

Aprotinin is a competitive serine protease inhibitor. Reversibly binds to and blocks the enzymatic active site. Inhibits a range of serine proteases including trypsin, chymotrypsin, kallikrein and plasmin. Inhibits cytopathogenic effect of SARS-CoV-2 and double-stranded RNA formation in SARS-CoV-2-infected cells.

This product is from Bovine Lung.

Product Specifications for Aprotinin

Molecular Weight

6511.48

Formula

C284H432N84O79S7

Storage

Store at +4°C

CAS Number

9087-70-1

PubChem ID

53487898

InChI Key

ZPNFWUPYTFPOJU-YSFZTAPISA-N

SMILES

[H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCSC)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC3=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N2)NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC1=O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 4mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 39 publications citing the usage of this product.

Product Documents for Aprotinin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Aprotinin

For research use only

Customer Reviews for Aprotinin (2)

4.5 out of 5
2 Customer Ratings
5 Stars
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4 Stars
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3 Stars
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2 Stars
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1 Stars
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  • Aprotonin 10mg
    Name: Anonymous
    Species: Human
    Verified Customer | Posted 11/11/2024
    Used to make a buffer for an ELISA kit (DYC1047-2). Worked well.
  • surgery research
    Name: Anonymous
    Verified Customer | Posted 05/30/2018
    Used in surgery research. Reduces inflammation and bleeding. Reasonably priced. You can dilute this aprotinin depending on your intended use, though dilute solutions are typically less stable. Will definitely purchase from R&D again.

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