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Aprotinin

Catalog #: 4139
1 Citation 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4139/10
Aprotinin
1 Image
Description: Competitive serine protease inhibitor
Product Details
Citations (1)
Reviews (1)
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Aprotinin is a competitive serine protease inhibitor. Reversibly binds to and blocks the enzymatic active site. Inhibits a range of serine proteases including trypsin, chymotrypsin, kallikrein and plasmin. Inhibits cytopathogenic effect of SARS-CoV-2 and double-stranded RNA formation in SARS-CoV-2-infected cells.

This product is from Bovine Lung.

Technical Data

M.Wt:
6511.48
Formula:
C284H432N84O79S7
Sequence:
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA

(Modifications: Disulfide bridges: 5-55, 14-38, 30-51)

Solubility:
Soluble to 10 mg/ml in water
Storage:
Store at +4°C
CAS No:
9087-70-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
  • from Bovine Lung

Background References

  1. Elastase and tryptase govern TNFa-mediated production of active chemerin by adipocytes.
    Parlee et al.
    PLoS ONE, 2012;7:e51072
  2. Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.
    Reichel et al.
    PLoS ONE, 2011;6:e17229
  3. SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles.
    Bojkova et al.
    BioRxiv - Paper not yet peer reviewed., 2020;

Product Datasheets

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Reconstitution Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for Aprotinin

The citations listed below are publications that use Tocris products. Selected citations for Aprotinin include:

1 Citation: Showing 1 - 1

  1. Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation.
    Authors: Berg Et al.
    Cell Rep  2019;27:2837

FAQs

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Reviews for Aprotinin

Average Rating: 4 (Based on 1 Review)

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surgery research
By Anonymous on 05/30/2018

Used in surgery research. Reduces inflammation and bleeding. Reasonably priced. You can dilute this aprotinin depending on your intended use, though dilute solutions are typically less stable. Will definitely purchase from R&D again.

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