Biological ActivityAprotinin is a competitive serine protease inhibitor. Reversibly binds to and blocks the enzymatic active site. Inhibits a range of serine proteases including trypsin, chymotrypsin, kallikrein and plasmin. Inhibits cytopathogenic effect of SARS-CoV-2 and double-stranded RNA formation in SARS-CoV-2-infected cells.
This product is from Bovine Lung.
(Modifications: Disulfide bridges: 5-55, 14-38, 30-51)
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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- from Bovine Lung
Elastase and tryptase govern TNFa-mediated production of active chemerin by adipocytes.
Parlee et al.
PLoS ONE, 2012;7:e51072
Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.
Reichel et al.
PLoS ONE, 2011;6:e17229
SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles.
Bojkova et al.
BioRxiv - Paper not yet peer reviewed., 2020;
Citation for Aprotinin
The citations listed below are publications that use Tocris products. Selected citations for Aprotinin include:
1 Citation: Showing 1 - 1
Proteolytic and Opportunistic Breaching of the Basement Membrane Zone by Immune Cells during Tumor Initiation.
Authors: Berg Et al.
Cell Rep 2019;27:2837
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Reviews for Aprotinin
Average Rating: 4 (Based on 1 Review)
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Used in surgery research. Reduces inflammation and bleeding. Reasonably priced. You can dilute this aprotinin depending on your intended use, though dilute solutions are typically less stable. Will definitely purchase from R&D again.