Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Biological ActivityAllosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
The unfolded protein response signals through high-order assembly of Ire1.
Korennykh et al.
Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors.
Wang et al.
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