APY 29

Key Product Details

Product Description

APY 29 is an allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC₅₀ = 280 nM) and activates IRE1α ribonuclease activity.

Product Specifications for APY 29

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for APY 29

The following data is based on the product molecular weight 332.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.04 mL	30.09 mL
5 mM	0.60 mL	3.01 mL	6.02 mL
10 mM	0.30 mL	1.50 mL	3.01 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Korennykh The unfolded protein response signals through high-order assembly of Ire1. Nature 2009 PMID: 19079236
• Wang Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat.Chem.Biol. 2012 PMID: 23086298

Product Documents for APY 29