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APY 29

4865 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4865/10
4865/50

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APY 29 | CAS No. 1216665-49-4 | Additional IRE1 Compounds
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Description: Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity

Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

APY 29 is an allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.

Technical Data

M.Wt:
332.36
Formula:
C17H16N8
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1216665-49-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for APY 29

The citations listed below are publications that use Tocris products. Selected citations for APY 29 include:

1 Citation: Showing 1 - 1

  1. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
    Authors: Govindarajan Et al.
    Nat Commun  2018;9:5340

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