Catalog Number: 4865
Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Biological Activity
Allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.
Technical Data
  • M.Wt:
    332.36
  • Formula:
    C17H16N8
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1216665-49-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The unfolded protein response signals through high-order assembly of Ire1.
    Korennykh et al.
    Nature, 2009;457:687
  2. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors.
    Wang et al.
    Nat.Chem.Biol., 2012;8:982

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