Home / Additional IRE1 Compounds / APY 29

APY 29

4865 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4865/10
4865/50
APY 29 | CAS No. 1216665-49-4 | Additional IRE1 Compounds
1 Image
Description: Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity

Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

APY 29 is an allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.

Technical Data

M.Wt:
332.36
Formula:
C17H16N8
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1216665-49-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for APY 29

The citations listed below are publications that use Tocris products. Selected citations for APY 29 include:

1 Citation: Showing 1 - 1

  1. Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
    Authors: Govindarajan Et al.
    Nat Commun  2018;9:5340

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for APY 29

There are currently no reviews for this product. Be the first to review APY 29 and earn rewards!

Have you used APY 29?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.