Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Biological ActivityAllosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The unfolded protein response signals through high-order assembly of Ire1.
Korennykh et al.
Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors.
Wang et al.
Citation for APY 29
The citations listed below are publications that use Tocris products. Selected citations for APY 29 include:
1 Citation: Showing 1 - 1
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Authors: Govindarajan Et al.
Nat Commun 2018;9:5340
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