Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Biological ActivityAPY 29 is an allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
The unfolded protein response signals through high-order assembly of Ire1.
Korennykh et al.
Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors.
Wang et al.
Citation for APY 29
The citations listed below are publications that use Tocris products. Selected citations for APY 29 include:
1 Citation: Showing 1 - 1
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Authors: Govindarajan Et al.
Nat Commun 2018;9:5340
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for APY 29
There are currently no reviews for this product. Be the first to review APY 29 and earn rewards!
Have you used APY 29?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image