APY 29
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Description: Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity
Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
Purity: ≥98%
Biological Activity
Allosteric modulator of IRE1α. Inhibits IRE1α autophosphorylation (IC50 = 280 nM) and activates IRE1α ribonuclease activity.Technical Data
M.Wt:
332.36
Formula:
C17H16N8
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1216665-49-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
The unfolded protein response signals through high-order assembly of Ire1.
Korennykh et al.
Nature, 2009;457:687 -
Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors.
Wang et al.
Nat.Chem.Biol., 2012;8:982
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