Inducible nitric oxide synthase (iNOS) inhibitor; selective for iNOS over eNOS (IC50
values are 0.037 and >100 μ
M for iNOS and eNOS respectively). Exhibits antinociceptive and anti-inflammatory activity in rodent pain models.
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1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
Tinker et al.
Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and postoperative pain.
LaBuda et al.
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, Part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
Bonnefous et al.