Catalog Number: 1637
Chemical Name: (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
Biological Activity
Potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.
Technical Data
  • M.Wt:
    508.63
  • Formula:
    C23H36N6O5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    74863-84-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
  • This compound is a mixture of 2 diastereomers (approximate ratio 65/35)
Background References
  1. Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition.
    Jang et al.
    Circulation, 1990;81:219
  2. Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid.
    Kikumoto et al.
    Biochemistry, 1984;23:85
  3. Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator.
    Fitzgerald and Fitzgerald
    Proc.Natl.Acad.Sci.USA, 1989;86:7585

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