Potent inhibitor of thrombin mediated fibrinogen cleavage (Ki
= 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
- This compound is a mixture of 2 diastereomers (approximate ratio 65/35)
Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition.
Jang et al.
Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid.
Kikumoto et al.
Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator.
Fitzgerald and Fitzgerald