Argatroban

Catalog # Availability Size / Price Qty
1637/10
1637/50
Argatroban | CAS No. 74863-84-6 | Additional Synthetic Protease Inhibitors
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Description: Potent thrombin inhibitor

Chemical Name: (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid

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Biological Activity

Potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.

This compound is a mixture of 2 diastereomers (approximate ratio 65/35).

Technical Data

Formula:
C23H36N6O5S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in 1eq. HCl
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
74863-84-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:
  • This compound is a mixture of 2 diastereomers (approximate ratio 65/35)

Background References

  1. Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid.
    Kikumoto et al.
    Biochemistry, 1984;23:85
  2. Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition.
    Jang et al.
    Circulation, 1990;81:219
  3. Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator.
    Fitzgerald and Fitzgerald
    Proc.Natl.Acad.Sci.USA, 1989;86:7585

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