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ArMan

Catalog #: 8869 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8869/2

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ArMan | Buffers, Chelators and Reagents
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Description: DC-SIGN ligand used to target dendritic cells

Chemical Name: N-(4-(((2R,3S,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenethyl)pent-4-ynamide

Purity: ≥98%

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Biological Activity

ArMan is an aryl mannoside targeting ligand that can be functionalised to the surface of virus like particles (VLPs) via click chemistry. Functionalised particles can be used to target DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin) dendritic cells to promote selective coengagement of DC-SIGN and TLR7, resulting in a Th1-type immune response. In vivo, immunization with VLP-ArMan-OvaI/II significantly inhibits tumor growth in a murine melanoma model.

Technical Data

M.Wt:
379.41
Formula:
C19H25NO7
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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