Catalog Number: 2622
Chemical Name: (R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
Biological Activity
Selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).
Technical Data
  • M.Wt:
    406.5
  • Formula:
    C20H26N2O5S
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    849773-63-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides.
    Tuccinardi et al.
    Bioorg.Med.Chem., 2006;14:4260
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ARP 101 include:

2 Citations: Showing 1 - 2
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  1. PDGF-stimulated dispersal of cell clusters and disruption of fibronectin matrix on three-dimensional collagen matrices requires matrix metalloproteinase-2.
    Authors: Rocha-Azevedo Et al.
    Hum Reprod 2015;26:1098
  2. NME1 suppression promotes growth, adhesion and implantation of endometrial stromal cells via Akt and MAPK/Erk1/2 signal pathways in the endometriotic milieu.
    Authors: Li Et al.
    Oncotarget 2013;28:2822

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