Chemical Name: 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
Biological ActivitySuppresses ROS-induced activation of the NLRP3 inflammasome. Arrests cell cycle in the G2/M phase and sensitizes human renal cell carcinoma (RCC) cell lines to sorafenib in vitro. Antimalarial.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Artemisinin: mechanisms of action, resistance and toxicity.
Meshnick et al.
Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis.
Jeong et al.
Artesunate inhibits renal ischemia-reperfusion-mediated remote lung inflammation through attenuating ROS-induced activation of NLRP3 inflammasome.
Liu et al.
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