AS 1517499

Key Product Details

Product Description

AS 1517499 is a potent STAT6 inhibitor (IC₅₀ = 21 nM). In vitro, it inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC₅₀ = 2.3 nM), without influencing Th1 differentiation induced by IL-12. In a mouse model of allergic bronchial asthma, treatment with AS 1517499 reduces mouse airway IL-3 production and partly inhibits the RhoA upregulation in bronchial smooth muscles.

Product Specifications for AS 1517499

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for AS 1517499

The following data is based on the product molecular weight 397.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.03 mL	25.13 mL	50.27 mL
2.5 mM	1.01 mL	5.03 mL	10.05 mL
5 mM	0.50 mL	2.51 mL	5.03 mL
25 mM	0.10 mL	0.50 mL	1.01 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Nagashima Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine- 5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorg.Med.Chem. 2008 PMID: 18534856
• Nagashima Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorg.Med.Chem. 2007 PMID: 17071093
• Chiba A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. Am.J.Respir.Cell Mol.Biol. 2009 PMID: 19202006

Product Documents for AS 1517499