AS 1842856

Catalog # Availability Size / Price Qty
4265/50
4265/10
Additional Transcription Factor Compounds Small Molecule
1 Image
Description: Potent and selective Foxo1 inhibitor; orally bioavailable

Chemical Name: 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective Foxo1 inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively. Regulates gluconeogenesis both in vitro and in vivo. Attenuates fasting plasma glucose level in diabetic db/db mice. Also suppresses autophagy, adipocyte differentiation and soluble guanylyl cyclase expression. Orally bioavailable.

Technical Data

M.Wt:
347.39
Formula:
C18H22FN3O3
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
836620-48-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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