Chemical Name: (2S)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin
Biological ActivityAS 19 is a potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo. AS 19 also promotes melanin synthesis in B16F10 murine melanoma cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats.
Horiguchi et al.
Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task.
Perez-Garcia and Meneses
Behav.Brain Res., 2005;163:136
An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation.
Perez-Garcia et al.
Behav.Brain Res., 2006;169:83
Citations for AS 19
The citations listed below are publications that use Tocris products. Selected citations for AS 19 include:
4 Citations: Showing 1 - 4
Serotonin/5-HT7 receptor provides an adaptive signal to enhance pigmentation response to environmental stressors through cAMP-PKA-MAPK, Rab27a/RhoA, and PI3K/AKT signaling pathways
Authors: Tang Et al.
FASEB J 2023;37:e22893
Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis.
Sci Rep 2017;7(1):14761
Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
Authors: Majeed Et al.
Neural Plast 2016;2016:7291438
5-HT is a potent relaxant in rat superior mesenteric veins.
Authors: Watts Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for AS 19
There are currently no reviews for this product. Be the first to review AS 19 and earn rewards!
Have you used AS 19?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image