Catalog Number: 1968
Chemical Name: (2S)-(+)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin
Biological Activity
Potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task.
    Perez-Garcia and Meneses
    Behav.Brain Res., 2005;163:136
  2. An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation.
    Perez-Garcia et al.
    Behav.Brain Res., 2006;169:83
  3. The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats.
    Horiguchi et al.
    J.Pharmacol.Exp.Ther., 2011;338:605

The citations listed below are publications that use Tocris products. Selected citations for AS 19 include:

1 Citations: Showing 1 - 1

  1. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    Neuropsychopharmacology 2015;3:e00103

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