Chemical Name: (2S)-5-(1,3,5-Trimethylpyrazol-4-yl)-2-(dimethylamino)tetralin
Biological ActivityAS 19 is a potent 5-HT7 receptor agonist (IC50 = 0.83 nM). Enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo.
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The role of 5-hydroxytrpytamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats.
Horiguchi et al.
Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task.
Perez-Garcia and Meneses
Behav.Brain Res., 2005;163:136
An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation.
Perez-Garcia et al.
Behav.Brain Res., 2006;169:83
Citations for AS 19
The citations listed below are publications that use Tocris products. Selected citations for AS 19 include:
3 Citations: Showing 1 - 3
Serotonin drives the acquisition of a profibrotic and anti-inflammatory gene profile through the 5-HT7R-PKA signaling axis.
Sci Rep 2017;7(1):14761
Modulatory Action by the Serotonergic System: Behavior and Neurophysiology in Drosophila melanogaster.
Authors: Majeed Et al.
Neural Plast 2016;2016:7291438
5-HT is a potent relaxant in rat superior mesenteric veins.
Authors: Watts Et al.
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