AS 2444697

Catalog # Availability Size / Price Qty
5430/10
5430/50
AS 2444697 | CAS No. 1287665-60-4 | IRAK Inhibitors
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Description: Potent and selective IRAK4 inhibitor

Chemical Name: N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (1)
Reviews (3)

Biological Activity

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

Technical Data

M.Wt:
432.86
Formula:
C19H20N6O4.HCl
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1287665-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for AS 2444697

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Reviews for AS 2444697

Average Rating: 4.7 (Based on 3 Reviews)

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In vivo
By Anonymous on 08/07/2021
Application: Species: Mouse

In vivo study


In vitro study
By Anonymous on 02/28/2021
Application: Species: Human

In vitro time/conc treatment


oral admingistration
By Anonymous on 11/29/2018
Application: Species: Mouse

0.5 % methylcellulose solution


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