AS 2444697

Tocris Bioscience | Catalog # 5430

Potent and selective IRAK4 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective IRAK4 inhibitor
View all IRAK Inhibitors »

Product Description

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

Product Specifications for AS 2444697

Molecular Weight

432.86

Formula

C19H20N6O4.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride

CAS Number

1287665-60-4

PubChem ID

118719434

InChI Key

FGNHLIIFEDYNFZ-UHFFFAOYSA-N

SMILES

O=C(N)C2=NN(C=C2NC(C3=COC(C4=CC=NC(C)=C4)=N3)=O)C1CCOCC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.66 20 with gentle warming

Preparing Stock Solutions for AS 2444697

The following data is based on the product molecular weight 432.86.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 11.55 mL 57.76 mL 115.51 mL
1 mM 2.31 mL 11.55 mL 23.10 mL
2 mM 1.16 mL 5.78 mL 11.55 mL
10 mM 0.23 mL 1.16 mL 2.31 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

Product Documents for AS 2444697

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for AS 2444697

For research use only

Customer Reviews for AS 2444697 (3)

4.7 out of 5
3 Customer Ratings
5 Stars
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4 Stars
33%
3 Stars
0%
2 Stars
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1 Stars
0%

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  • In vivo
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 08/07/2021
    In vivo study
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    Species: Human
    Verified Customer | Posted 02/28/2021
    In vitro time/conc treatment
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    Assay Type: In Vivo
    Verified Customer | Posted 11/29/2018
    0.5 % methylcellulose solution

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