Chemical Name: N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
Biological ActivityAS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders.
Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats.
Kondo et al.
Naunyn Schmiedebergs Arch.Pharmacol., 2014;387:909
Blocking innate immunity to slow the progression of chronic kidney disease.
Schmaderer and Heemann
Naunyn Schmiedebergs Arch.Pharmacol., 2014;387:905
Citation for AS 2444697
The citations listed below are publications that use Tocris products. Selected citations for AS 2444697 include:
1 Citation: Showing 1 - 1
Tumor-Stroma IL1β-IRAK4 Feedforward Circuitry Drives Tumor Fibrosis, Chemoresistance, and Poor Prognosis in Pancreatic Cancer.
Authors: Zhang Et al.
Cancer Res 2018;78:1700
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In vivo study
In vitro time/conc treatment
0.5 % methylcellulose solution