AS 2444697

Catalog # Availability Size / Price Qty
5430/10
5430/50
IRAK Inhibitors Small Molecule
1 Image
Description: Potent and selective IRAK4 inhibitor

Chemical Name: N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

Potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC50 = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

Technical Data

M.Wt:
432.86
Formula:
C19H20N6O4.HCl
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1287665-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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oral admingistration
By Anonymous on 11/29/2018
Species: Mouse

0.5 % methylcellulose solution


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