Chemical Name: (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid
Biological ActivityASP 7663 is a selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain.
Kojima et al.
Citations for ASP 7663
The citations listed below are publications that use Tocris products. Selected citations for ASP 7663 include:
2 Citations: Showing 1 - 2
A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery.
Authors: Ko Et al.
Sci Rep 2019;9:2430
Bladder Dysfunction in an Obese Zucker Rat: The Role of TRPA1 Channels, Oxidative Stress, and Hydrogen Sulfide.
Authors: Blaha Et al.
Oxid Med Cell Longev 2019;2019:5641645
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