Catalog Number: 5795
Biological Activity
CXCR4 allosteric agonist (EC50 = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards Gi proteins over G13 and β-arrestin.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Met-1 = N-terminal Palmitoyl)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
    Tchernychev et al.
    Proc.Natl.Acad.Sci.U.S.A., 2010;107:22255
  2. Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor.
    Planesas et al.
    J.Mol.Graph Model., 2015;60:1
  3. Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.
    Quoyer et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:E5088
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