ATI 2341

Name: ATI 2341
Brand: Tocris Bioscience
SKU: 5795
Price: 299 USD
Availability: InStock

Tocris Bioscience | Catalog # 5795

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Citations (2)

Product Documents

CXCR4 allosteric agonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

CXCR4 allosteric agonist

View all Chemokine Receptor Agonists »

Product Description

ATI 2341 is a CXCR4 allosteric agonist (EC₅₀ = 194 nM). Induces chemotaxis in CXCR4-expressing cells in vitro. Mobilizes polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs) from bone marrow niche in vivo. Exhibits biased signaling towards G_i proteins over G₁₃ and β-arrestin.

Product Specifications for ATI 2341

Molecular Weight

2256.82

Formula

C₁₀₄H₁₇₈N₂₆O₂₅S₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1337878-62-2

PubChem ID

101961246

InChI Key

YMLOFEANRZSEGQ-QNHYGVTPSA-N

SMILES

CCCCCCCCCCCCCCCC(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Mass

Concentration

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g/mol

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Background References

References are publications that support the biological activity of the product.

Planesas Studying the binding interactions of allosteric agonists and antagonists of the CXCR4 receptor. J.Mol.Graph Model. 2015 PMID: 26080355
Quoyer Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein. Proc.Natl.Acad.Sci.U.S.A. 2013 PMID: 24309376
Tchernychev Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc.Natl.Acad.Sci.U.S.A. 2010 PMID: 21139054

Product Documents for ATI 2341

Certificate of Analysis

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Download SDS

Product Specific Notices for ATI 2341

For research use only

Citations for ATI 2341

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