Chemical Name: 1H-Indole-3-acetic acid
Biological ActivityChemical dimerizer used in auxin-inducible degron (AID) systems. Induces degradation of a target protein tagged with the Tir1 E3 ligase AID in human colorectral cancer and mouse ES cells. Endogenous plant hormone.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
An auxin-based degron system for the rapid depletion of proteins in nonplant cells.
Nishimura et al.
Rapid protein depletion in human cells by auxin-inducible degron tagging with short homology donors.
Natsume et al.
Cell Rep., 2016;15:210
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