Chemical Name: 2,6-Diisopropylphenyl (2-(2,4,6-triisopropylphenyl)acetyl)sulfamate
Biological ActivityAvasimibe is an ACAT inhibitor (IC50 = 3.3 μM). Inhibits cholesterol esterification and reduces plasma cholesterol levels in rats. Also inhibits tumor growth and prolongs survival time in a melanoma mouse model and reduces tumor growth and metastasis in a pancreatic cancer mouse model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. CI-1011: an acyl sulfamate with unique cholesterol-lowering activity in animals fed noncholesterol-supplemented diets.
Lee et al.
Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism.
Yang et al.
Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer.
Li et al.
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