AVE 1625

Catalog # Availability Size / Price Qty
6763/50
6763/10
AVE 1625 | CAS No. 358970-97-5 | Cannabinoid R1/CB1 Antagonists
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Description: Potent and selective CB1 receptor antagonist
Alternative Names: Drinabant

Chemical Name: N-[1-[Bis(4-chlorophenyl)methyl]-3-azetidinyl]-N-(3,5-difluorophenyl)methanesulfonamide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective CB1 receptor antagonist (IC50 values are 25 and 10 nM for human and rat CB1R, respectively). Exhibits >400-fold selectivity for CB1 over CB2 receptors. Attenuates Olanzapine (Cat. No. 4349) induced weight gain and food intake in rats with no effect on energy expenditure or motility. Also improves cognitive function in rodent schizophrenia models and ameliorates extrapyramidal side-effects of antipsychotics.

Technical Data

M.Wt:
497.38
Formula:
C23H20Cl2F2N2O2S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
358970-97-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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